The antigen's foreignness is the most important determinant of immunogenicity when considering an antigen.
An antigen in immunology is a molecule, molecular structure, foreign particle, pollen grain, etc. that may attach to a particular antibody or T-cell receptor. Antigens within the body may cause an immunological response.
Antigens are outside elements. Normally, the body's defence cells don't react to molecules that belong to it (self antigen). A substance's antigenicity is often correlated with its foreignness . When compared to antigen from other members of the same species, it is less antigenic.
A foreign substance must make up the immunogen. Only substances that are not normally found in the body or exposed to the cells of the particular immune system trigger immune reactions. The immune system will distinguish between "self" and "non-self" in normal circumstances.
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