Answer Abnormal protein buildup, called amyloidosis
Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
Mental health is affected by physical factors such as disease or brain injury and by environmental factors such as stress or unemployment.
Mental health is one of the spheres of health. This comprises the mind related to psychological and emotional wellbeing.
This sphere can be affected by other factors or sphere including:
- Environmental factors
- Physical factors
- Social factors
In the case of environmental factors this includes factors such as stress or unemployment, these affect mental health because they make a person more likely to develop certain conditions such as stress.
On the other hand, physical factors include factors such as disease or brain injury. The two factors have also been proven to make an individual more vulnerable to certain mental diseases.
Note: This question is incomplete because the statements are not given. Due to this, I answered it based on general knowledge.
Learn more in: brainly.com/question/2655226
Galen was a renew physician during the Middle Ages and Hippocrates believe that there are four humor in the body that which brings balance for a healthy life
Blood
Yellow bile
Black bile
Phlegm
