Question

Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo.

Answer 1

As "nurse" cells for neurons in the brain parenchyma, astrocytes are resident glial cells produced from neuroectoderm.

How astrocytes become pathological?

• Recent research has identified astrocytes as major disease-propagating agents in mutant human superoxide dismutase 1 (mSOD1)-mediated amyotrophic lateral sclerosis (ALS).
• However, due to the widespread expression of mSOD1 throughout the CNS of the investigated rodent models, in vivo examination of a specific astrocytic effect in amyotrophic lateral sclerosis has proven challenging.
• In order to understand how mutant astrocytes affect WT MNs and other cell types (microglia and astrocytes) in an in vivo environment, we transplanted SOD1(G93A) glial-restricted precursor cells into the cervical spinal cord of WT rats.
• SOD1(G93A) glial-restricted progenitor cells that were transplanted survived and successfully differentiated into astrocytes.

Learn more about the Astrocytes with the help of the given link:

brainly.com/question/14747164

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