The answer will be increase slightly and then decrease. Hope you get it!
The intended response fails to be produced.*In order for a drug to produce its intended response, its blood levels must reach the minimum effective concentration. When enzymes responsible for metabolizing and preparing drugs for elimination are more active as a result of a genetic variation, sensitive drugs are eliminated more rapidly, and a "normal" dose may not be high enough to allow the drug to be retained long enough to reach the MEC.
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Hope i help!