Answer:
1. The difference between the normal hemoglobin protein DNA sequence and the sickle cell hemoglobin DNA sequence is a base to base shift, in this case adenine (GAG) to thymine (GTG).
2. The difference affects the amino acid sequence of the protein by replacing glutamic acid (Glu) with valine (Val).
Explanation:
In sickle cell anemia, a change in the DNA nucleotide sequence is observed, where adenine is substituted by thymine, whose expression is the change in the amino acid sequence of globine β, incorporating valine instead of glutamic acid. This represents a molecular mutation - point mutation - by subtitution, which corresponds to missense mutation.
<u>Normal hemoglobin protein in a RBC</u>
DNA CTG ACT CCT GAG GAG AAG TCT
Amino acids Leu Thr Pro Glu Glu Lys Ser
<u>Sickle cell hemoglobin protein in a RBC</u>
DNA CTG ACT CCT <em>GTG</em> GAG AAG TCT
Amino acids Leu Thr Pro <em>Val</em> Glu Lys Ser
When GAG is transcribed to mRNA, the CUC codon is obtained, which codes for glutamic acid. Thymine substitution causes the DNA sequence to change to GTG, which is transcribed as CAC, the codon that encodes the amino acid valine. The <u>change from glutamic acid to valine in β-globin causes an altered hemoglobin, giving the abnormal erythrocytes observed in sickle cell disease</u>.
Answer:
Option E, C tactile (CT) afferent
Explanation:
Whenever a slow moving gentle touch experienced, the response is due to the nerve fibers called C-Tactile afferents (CTs).
C-Tactile afferents (CTs) are unmyelinated mechanoreceptors of low threshold and low conduction velocities.
In humans, CT neurons are found in hairy skin.
The pleasant feeling observed during a slow gentle touch is due to the interaction of
CT neurons project to the insular cortex in the brain
Hence, option E is correct
The population of the mice would most likely increase. This is because the number of predators of mice will decrease. Predators are those that feed on others, in this case mice. When predators decrease, the prey (which would be the mice) will be able to populate thus leading to an increase in population.
Its b or d
Explanation:
None