I believe the answer is B., Hopefully I'm correct!
Virus: Vaccine, Antibiotics are not useful, Is not an organism
Both: Curable, Harmful to humans, Deadly
Bacteria: No vaccine, Antibiotics are useful, Is an organism
You would expect an earthworm to have no exoskeleton because as you see it is very flexible and soft. Organisms with such have body parts that are divided and an earthworm do not have any visible parts on them also having an exoskeleton would not allow an organism to move like an earthworm does.
<span>d. only the fittest of sperm and egg combinations will survive.
Others are external fertilization:
</span>a. all of the sperm will fertilize eggs.
b. sperm and egg will be released simultaneously.
c. the number of sperm and eggs produced will be equal.
<span>e. sperm will be protected until they can unite with the eggs.</span><span>
</span>
Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
