Question

Describe an approach for understanding global systems and the changes they undergo

Answer 1

Answer:

It is to apply genomic knowledge effectively in

drug discovery, mechanistic connectivities

between genetic variation and disease

processes need to be established via

systems biology approaches. Humans have

hundreds of functionally specialized cell

types that interact differentially with

environmental factors to influence disease

development and to modulate the effects of

drugs. Metabonomics can provide a means

of modelling these interactions, but the

relationships between ‘endogenous’

metabolic processes and

‘xenobiotic’ metabolism

are poorly understood, especially with

respect to environmental factors. We

present an overview of ‘global’ mammalian

metabolic conversions that should be

accounted for in human systems biology

models and propose a new probabilistic. Approach to help understand gene–disease relationships and vexed

issues of idiosyncratic drug toxicit etc.

Thus this is the required answer.  

Explanation:

Answer 2

Solution:

It is to apply genomic knowledge effectively in

drug discovery, mechanistic connectivities

between genetic variation and disease

processes need to be established via

systems biology approaches. Humans have

hundreds of functionally specialized cell

types that interact differentially with

environmental factors to influence disease

development and to modulate the effects of

drugs. Metabonomics can provide a means

of modelling these interactions, but the

relationships between ‘endogenous’

metabolic processes and

‘xenobiotic’ metabolism

are poorly understood, especially with

respect to environmental factors. We

present an overview of ‘global’ mammalian

metabolic conversions that should be

accounted for in human systems biology

models and propose a new probabilistic. Approach to help understand gene–disease relationships and vexed

issues of idiosyncratic drug toxicit etc.

Thus this is the required answer.