Yes, it is true that Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia.
Focal malformations of cortical development, including focal cortical dysplasia (FCD) and hemimegalencephaly (HME), are important causes of intractable childhood epilepsy.
Using targeted and exome sequencing on DNA from resected brain samples and non-brain samples from 53 patients with FCD or HME, we identified pathogenic germline and mosaic mutations in multiple PI3K/AKT pathway genes in 9 patients, and a likely pathogenic variant in 1 additional patient.
Our data confirm the association of DEPDC5 with sporadic FCD but also implicate this gene for the first time in HME. Our findings suggest that modulation of the mammalian target of rapamycin pathway may hold promise for malformation-associated epilepsy.
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Answer:
Answer 1= Leafs
Answer 2= Multicellular
#1- The leafs on a plant take in co2 and relese oxygen
#2 Multicellular means that there Multiple cells
Please mark me brainliest if it helps!
The menstrual cycle is practically controlled by a system of hormones that is necessary for reproduction, and when the hormone reaches a heightened level, something called estradiol is made, then the stimulation of the ovaries by a luteinizing hormone.
Once that hormone begins developing, the ovaries make an egg that quickly becomes an ovum. The ovary then releases one egg or two during ovulation. The endometrium (the part that sheds its own cells for the menstruation) peaks after ovulation and changes the lining of the uterus to prepare for the hectic process of pregnancy and child labor.
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