If the size of a cell increases it will be more difficult (all other things being equal) for diffusion to transport materials out of the cell. Therefore, less of the cell's interior will be able to come in contact with the cell's surface. If less of it comes in contact, less of it can cross the cell membrane.
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Phenotype and genotype. The genotype of an organism<span> is defined as the sum of all its genes. The phenotype of an </span>organism<span> is the observable physical or biochemical characteristics of an </span>organism<span>, determined by both genetic make-up and environmental influences.</span>