The treatment of prions with denaturants reduces disease transmission because prions do not contain genetic information, which is affected by ionizing radiation.
Further Explanation:
Disease transmission can be defined as a process which involves the <u>transfer of infectious agent from one individual to another</u>. This transmission can be direct or indirect depending upon the mode of the transfer of the agent to an individual.
The term prion refers to protein infection particle. Normal prion protein is a protein on the surface of the cells which is encoded by a PRNP gene. Mutation in the PRNP gene results in abnormal or misfolded prion protein. Altered prions contains proteinaceous infectious particle which can transmit disease by inducing normal proteins to become misfolded ones.
Treatment of prion preparations with ionizing and UV-radiation does not reduce transmission of disease as it is not a genetic material or DNA. Denaturants can reduce disease transmission by denaturing the structure of misfolded protein which cannot reform again to become infectious.
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Answer Details:
Grade: College Biology
Subject: Biology
Chapter: Life processes-Virus
Keywords:
Prion, protein infection particle, proteinaceous infectious particle, denaturants, misfolded protein, PRNP gene.
