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Svetradugi [14.3K]
3 years ago
12

Knowledge of the driver mutations underlying cancer has led to targeted therapeutics, such as the protein kinase inhibitor imati

nib (trade name Gleevec) in cases of chronic myeloid leukemia. Cancer cells often become resistant to a given drug, so researchers continue searching for new drugs that target proteins that contribute to the cancerous phenotype. One recent promising approach uses drugs that lead to ubiquitination and proteasomal degradation of the target protein. Which of the following mutated proteins are good candidates for this approach?
A) oncogenes
B) proteins with loss-of-function mutations
C) proteins with gain-of-function mutations
D) tumor suppressor genes
Biology
1 answer:
garik1379 [7]3 years ago
3 0

Answer:

<u>C) proteins with gain-of-function mutations</u>

Explanation:

<u>Gain-of-function mutations: </u>In biology, the term "gain-of-function mutation" is described as one of the different types of mutation in which the altered or changed "gene product" consists of an entirely new pattern or molecular function associated with gene expression. However, the "gene-of-function mutations" are being always considered as "Semidominant or Dominant".

<u>In the question above, the correct answer is option C.</u>

<u />

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A population of 100 tigers has 30 with horizontal stripes. Using pedigrees, you ascertain that horizontal striping is caused by
bixtya [17]

Assuming that this population is in Hardy-Weinberg equilibrium, we can sayt that  <em>the</em><em> probability</em><em> that, given enough time, all tigers in the population will have horizontal stripes is</em><em> 30% = 0.3.</em>

--------------------------

<u>Available data:</u>

  • Population size, N = 100 tigers
  • Number of Tigers with horizontal stripes = 30
  • Horizontal stripes is caused by an autosomal recessive mutation.

We need to know the probability that all tigers in the population will have horizontal stripes, which is the recessive phenotype.

We assume that the population is in Hardy-Weinberg equilibrium, so there should be no evolution.

Since the population is in H-W equilibrium, the allelic, genotypic and phenotypic frequencies will remain the same generation after generation.

Now, we will calculate the allelic and genotypic frequencies of horizontal striped individuals in the population.

There are 100 individuals, and only 30 have horizontal stripes.

So, the phenotypic frequency, F(HS) is 30/100 = 0.3 = 30%

Since this is a recessive phenotype, this value equals the genotypic frequency, F(hh) = 30%

Finally, we can get the allelic frequency by taking the square root of this value.

F(hh) = q² = 0.3

f(h) = q = √0.3 = 0.55 = 55%

According to these calcs, the probability for the fixation of the recessive allele is 55%, and the probability that all individuals express the recessive horizontal stripes phenotype is 30%.

--------------------------

You can learn more about Hardy-Weinberg equilibrium at

brainly.com/question/12724120?referrer=searchResults

brainly.com/question/9870841?referrer=searchResults

brainly.com/question/419732?referrer=searchResults

brainly.com/question/13603001?referrer=searchResults

brainly.com/question/5028378?referrer=searchResults

6 0
3 years ago
List and describe the three elements of media literacy
mariarad [96]

The first stage is simply becoming aware of the importance of managing one's media "diet"--- that is, making choices and reducing the time spent with television, videos, electronic games, films and various print media forms.

<span>The second stage is learning specific skills of critical viewing--- learning to analyze and question what is in the frame, how it is constructed and what may have been left out. Skills of critical viewing are best learned through inquiry-based classes or interactive group activities, as well as from creating and producing one's own media messages.
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The third stage goes behind the frame to explore deeper issues. Who produces the media we experience and for what purpose? Who profits? Who loses? And who decides? This stage of social, political and economic analysis looks at how everyone in society makes meaning from our media experiences, and how the mass media drive our global consumer economy. This inquiry can sometimes set the stage for various media advocacy efforts to challenge or redress public policies or corporate practices.


5 0
3 years ago
DNA is sometimes called the " blueprint of life" Why do you think that is?
quester [9]

Answer:

DNA is the blueprint of life because it is what tells our bodies what to make, how to make us , and what to give us.

7 0
3 years ago
Despite his fear of germs, Howard Hughes neglected his own hygiene despite having those around him follow strict cleanliness pra
KATRIN_1 [288]

Answer:

I want to say B. he developed OCD at an old age.

Explanation:

im not entirely sure this is correct so please tell me if its not! hope this helps!

4 0
3 years ago
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A cyclist rode at an average speed of 15 mph for 30 miles. How long was the ride?
fomenos

Answer:

A. 2 hrs

Hope This Helps!

3 0
3 years ago
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