Prokaryotes are the most primitive form of life that exist on earth. They came before eukaryotes.
The main difference is the presence of nucleus which is present in eukaryotes and absent in prokaryotes.
The genetic material of prokaryotes are dissolved in the cytoplasm whereas in case of eukaryotes the genetic material is in-tacked inside a double membrane organelle nucleus.
There are many more membrane bound cell organelles found in eukaryotes that are absent in prokaryotes.
