D. Watershed - a watershed is the area in which runoff, rivers, and streams run into a larger body of water
Answer: An error during transcription could produce a shorter protein or induce changes in the protein's sequence.
Explanation: Transcription is the process of single-stranded RNA synthesis from a DNA template (gene). During this process, RNA polymerase reads the DNA template and synthetize RNA, keeping the sequence. The RNA sequence will be reading later by ribosomes and protein will be produced. An error in transcription could produce changes in codons that are sequences of 3 nucleotides that determine aminoacids of the protein, and that would change protein folding and inactive it. Another possible result would be that error in transcription produce a premature stop codon that cause a shorter inactive protein.
Answer:
microvilli, actin filaments
Explanation:
The apical ends of intestinal cells face the intestinal channel and have long processes that facilitate the absorption of nutrients. the name of these processes is microvilli and actin filaments from the cytoskeletal element forms their internal skeleton.
Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
The Cerebellum is responsible for coordinating muscle movements and maintaining balance
