Answer:
i don't think the vaccine will help. a lot of people died from it.
Explanation:
Numerous degenerative neurological conditions, most notably Parkinson's disease, have been linked to an excessive buildup of alpha synuclein (a-syn) in the brain. Intraneuronal inclusions, often known as Lewy bodies, are neuropathological characteristics seen in Parkinson's disease, Lewy body dementia, and other synucleopathies. The aggregation of a-syn is their main structural component. A-syn accumulation, aggregation, and ensuing Lewy body formation can be attributed to a variety of biological processes. These include genetic changes in parkin, synuclein, or the deubiquitinating enzyme ubiquitin C-terminal hydrolase (UCH-L1), which results in less efficient removal of a-syn via the ubiquitin proteasomal pathway (UPP). Additionally, environmental variables and an age-related decline in antioxidant defense mechanisms that heighten oxidative stress and can have an impact on the formation or clearance of a-syn are intracellular insults.
We focused on changes in the aggregation and clearance of a-syn as impacted by the UPP and the oxidative stress pathways in our dynamic models of a-syn processing in both normal and various disease states. A free radical profile similar to that observed in vivo after exposure to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is produced during simulation of enhanced oxidative stress (MPTP). To replicate the kinetics of a-syn that correlates to the neuropathology reported for the sporadic and hereditary types of Parkinson's disease, different model parameters of oxidative stress, UPP failure, or both routes are used. With the use of this in silico model, it is possible to evaluate the kinetics of pathway elements and more accurately identify and validate key pharmaceutical targets.
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The teacher
should discuss safety procedure with students at the beginning of the experiment
or laboratory assignment. The teacher
should give list of rules for students.
1.
Always wear safety goggles.
2.
Never
touch or rub eyes of face during science investigation.
3.
Keep lids on when not in use.
4.
Never use broken/chipped glassware.
there is no clear evidence about plants evolving in the desert, or fossils of any kind of cactus despite their distribution over a large area. But, scientists are of the opinion that they acquired specific attributes millions of years ago, as a response to the vastly changing climate and conditions.
-Desert plant root system
A typical desert plant has a deep root system, which is a specific physical mechanism. As the roots grow deep down the soil, they absorb soil water, which is then transported to the upper portions of the plant.
-Desert plant leaves
Bear small foliage with waxy surface to minimize transpiration (loss of water through stomatal pores), which in turn, helps to conserve water.
