Question

Which of the following statements is TRUE?

Answer 1

Answer: B (GTP serves as the energy input for AMP synthesis from IMP)

Explanation:

In the de novo synthesis of purine nucleotide, IMP represents a branch point for purine biosynthesis. IMP can be converted to either AMP or GMP.

The formation of AMP from IMP requires GTP; similarly formation of GMP requires ATP. The conversion of IMP to either AMP or GMP is highly regulated – AMP and GMP inhibits their own formation by feedback inhibition of adenlyosuccinate synthetase and IMP dehydrogenase.