A current problem in modern medicine is the development of drug resistance mutations. This occurs when a mutation arises in a di
sease-causing microbe making it resistant to a drug and thus rendering the drug useless in treating a specific disease. Many useful drugs are competitive inhibitors of specific enzymes, and the drug-resistance mutations prevent the binding of the drug. These types of mutations, in addition to preventing competitive inhibitor binding, can also sometimes reduce the activity of the enzyme. Why is that the case?
The reason why drug-resistance mutations reduce certain enzymes activities is due to their inhibition because they cannot give bacterial respond to antibiotics.
Explanation:
In other words, enzymes use a series of specific strategies to overcome the toxic properties of antibiotics that, combined with a resistance agent, completely alter the performance of the drug. In addition, drug-resistance mutations contain fully evaded instruments which complicate the effectiveness of certain antibiotics, for example, penicillin.
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