Answer: c. +4
Explanation:
For formation of a neutral ionic compound, the charges on cation and anion must be balanced. The cation is formed by loss of electrons by metals and anions are formed by gain of electrons by non metals.




Here manganese is having an oxidation state of +4 called as cation and oxygen forms an anion with oxidation state of -2. Thus they combine and their oxidation states are exchanged to give
which written in simplest whole number ratios to give neutral 
The answer to this question would be: resistance
When a patient developing a resistance to a certain drug, the same amount of doses will not exert the same effect as before. The effect will be lower, thus the doctor will need to increase the dose to increase the effect
Would it be lack of water and food?
Answer
Sounds travel slowest in gasses so it would be air