Galactosemia caused by a transferase deficiency is characterized by elevated levels of galactose, galactitol, and galactose 1‑ph
osphate. Galactose and galactitol are precursors of galactose 1‑phosphate. Transferase deficiency studies in animal models suggest that galactose 1‑phosphate is the toxic agent. Which result from a galactosemia study in an animal model will implicate galactose 1‑phosphate as the toxic agent in a transferase deficiency? Inhibition of UDP‑glucose 4‑epimerase in affected animals prevents toxicity. Affected animals given a lactase inhibitor do not experience toxicity. Inhibition of galactose transporter in the intestinal cells prevents toxicity. Affected animals given a galactokinase inhibitor do not experience toxicity. A galactose‑free diet eliminates toxicity in affected animals.
Affected animals given a galactokinase inhibitor do not experience toxicity.
Explanation:
Galactokinase: Catalyzes is the first and committed step of the Leloir pathway involving the conversion of galactose to glucose. It causes phosphorylation of α-D-galactose to galactose 1‑phosphate. Thus, inhibiting galactokinase wil greatly decrease the levels of galactose 1‑phosphate.
<span>Two ATP </span><span> </span><span>During glycolysis, the overall gain of ATP per glucose molecule is 2. Although glycolysis produces 4 ATPs, it only uses 2 ATPs in the process!</span>
Since the death rate is higher than the birth rate we can assume that it will be negative. 5-15 is -10 for their life. immigration is also lower than the emigration. 2-4 is -2. adding -2 and -10 will give us -12, hope this helps.
