The last one or Mano but I’m think it’s indigenous
Answer:it was harder to get goods to other places
Explanation: hope this helps <3
That expansion of slavery was a major problem for the nation
Assuming you are talking about the Civil War most of the southern states began to secede from the Confederacy in the 1870s and began to unify with the Union.
Three reasons of the deaths of native Americans:
New illnesses that their immune systems couldn't cope with.
Genocides so the settlers could have the good land.
Starvation from lack of rations and poor infertile land on resevations