Didn't quit understand the question but if you were asking who basically came up with the idea of offspring inherited traits then the idea was proposed in ancient times by Hippocrates and Aristotle and was commonly accepted near to Lamarck's time.
For chemical reactions where the free energy of the reactants is much greater than the free energy of the products (DGo' < 0), the reaction proceeds spontaneously and the net result is a large ratio of product to reactant (large Keq).