The metabolic fate of fatty acids is dependent on two enzymes, carnitine acyltransferase i and acetyl-coa carboxylase. carnitine
acyltransferase i facilitates the transport of fatty acids to the mitochondria for β oxidation, whereas acetyl-coa carboxylase catalyzes the first reaction in the fatty acid synthesis pathway. the amp-activated protein kinase (ampk) regulates the activity of acetyl-coa carboxylase by phosphorylating a specific serine residue. mutation of this regulatory serine to alanine or aspartate would be expected to have different effects on the regulation of acetyl-coa carboxylase. select the statements that describe the expected effects of mutations of the regulatory serine.
If the regulatory serine is mutated to alanine, then acetyl-CoA carboxylase will get activated spontaneously and will produce malonyl-CoA. The increased concentrations of malonyl-CoA will obstruct the oxidation of fatty acids by preventing the entry of fatty acids into the mitochondria.
It is because the AMP-activated protein kinase phosphorylates the serine residues of acetyl-CoA carboxylase to inactivate it. If a mutation occurs in such residues, then the AMPL cannot phosphorylate acetyl-CoA carboxylase and this enzyme will get activated spontaneously.
In such a situation, there will be more than sufficient production of malonyl-CoA, which will inhibit the admittance of more fatty acid getting inside the mitochondria; this will indirectly prevent the oxidation of fatty acids.
Metals such as iron have low specific heat. It doesn't take much energy to raise their temperature. That's why a metal spoon heats up quickly when placed in a cup of hot coffee. Sand also has a relatively low specific heat.
Eating junk food on a regular basis can lead to an increased risk of obesity and chronic diseases like cardiovascular disease, type 2 diabetes, non-alcoholic fatty liver disease and some cancers. We know Australian's eat too much junk food. 35% of adults' daily energy intake (kilojoules) comes from junk food.
Database table is is made up of fields. A field is simply a data structure for a type-single piece of data.
Fields can be organized into what is known as records, which is one that contain all the information that (groups of the) table entails relevant to a specific entity in context.
