Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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The first statement is wrong because photosynthesis occur during day by plants, while respiration happens during day and night which are very related and they can be happened at the same time, in other hand photosynthesis cannot Accor in human cells because animal cells do not have chloroplasts which are using light energy to make glucose ,but in our cells or in animal cells we have mitochondria which break down the energy to make ATP....
for the second statement I'm not sure about that ....
I think that the third statement Is correct, because
the Cellular respiration make carbon dioxide + water + ATP then those would be then used by photosynthesis to make glucose and oxygen .
can I get brainlist pls?
Answer:
B. Disruptive Selection
Explanation:
the population is divided into two distinct groups, or is disrupted so the gentics start to vary between the separted populations over time.
Answer:
w and x
Explanation:
they both rise and fall in the same places but they are different heights
Answer:
(1) glycerophospholipids ⟶ (C) lipids with phosphate-containing head groups
(2) cerebrosides ⟶ (D) fatty acid linked through an amide bond to the sphingosine C(2)-amine
(3) gangliosides ⟶ (B) anionic sphingolipids containing one or more sialic acid residues
(4) sphingolipids ⟶ (A) built on sphingosine
Explanation:
1) Choline (Fig. 1) is a glycerophospholipid. It is a glycerol-based lipid with a phosphate-containing head group.
(2) Galactosylceramide (Fig. 2) is a cerebroside. It contains a fatty acid linked through an amide bond to the sphingosine C(2)-amine
(3) Gangliosides are glycosphingolipids that contain sialic acid. GQ1b (Fig. 3) is one of the most abundant gangliosides in the human brain. The carboxyl group of the sialic acid is in the ionic form.
(4) Sphingomyelin (Fig. 4) is a sphingolipid. It is based on sphingosine, with a phosphocholine head and a fatty acid chain.
