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DanielleElmas [232]
3 years ago
6

General transcription factors, along with TAFs, recruit ____________ and position it at the start of the protein-coding sequence

.
Biology
1 answer:
qaws [65]3 years ago
7 0
General transcription factors, along with TAFs, recruit RNA polymerase and position it at the start of the protein-coding sequence. <span>TAF is part of the transcription initiation protein complex or the Pre-initiation complex which has a role in starting the transcription. This complex mediates transcription of DNA to RNA by RNA polymerase II.</span>
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(Initial individuals + newborn individuals) - dead individuals = total individuals

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garri49 [273]

Answer:

1. The difference between the normal hemoglobin protein DNA sequence and the sickle cell hemoglobin DNA sequence is a base to base shift, in this case adenine (GAG) to thymine (GTG).

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Explanation:

In sickle cell anemia, a change in the DNA nucleotide sequence is observed, where adenine is substituted by thymine, whose expression is the change in the amino acid sequence of globine β, incorporating valine instead of glutamic acid. This represents a molecular mutation - point mutation - by subtitution, which corresponds to missense mutation.

<u>Normal hemoglobin protein in a RBC</u>

DNA                 CTG ACT CCT GAG GAG AAG TCT

Amino acids     Leu  Thr   Pro   Glu   Glu   Lys   Ser

<u>Sickle cell hemoglobin protein in a RBC</u>

DNA                 CTG ACT CCT <em>GTG</em> GAG AAG TCT

Amino acids     Leu  Thr   Pro   <em>Val</em>   Glu   Lys   Ser

When GAG is transcribed to mRNA, the CUC codon is obtained, which codes for glutamic acid. Thymine substitution causes the DNA sequence to change to GTG, which is transcribed as CAC, the codon that encodes the amino acid valine. The <u>change from glutamic acid to valine in β-globin causes an altered hemoglobin, giving the abnormal erythrocytes observed in sickle cell disease</u>.

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