How are cancer therapies tailored to nucleotide synthesis -explain using the example of fluorouracil and methotrexate.

Biology

1 answer:

nika2105 [10]4 years ago

3 0

Answer:

By preventing the synthesis of DNA halting cell growth.

Explanation:

Fluorouracil and methotraxate prevent the synthesis of the neucleoside Thymidine thus preventing DNA replication and elongation. Methotraxate has a structure analogous to Folic acid which is important for thymidine synthesis. Thus, it acts as a competitive inhibitor on dihdrofolate reductase an enzyme that is essential for tetrahydrofolate formation, a folic acid derivative.

Fluorouracil acts by inhibiting thymidylate synthase which catalyses an essential step in Thymidine synthesis.

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