Scientific notation is used in science because the number can be vary from so much that using decimal is making it hard. The number expressed in form. Both number in the question is already in scientific notation. Then to multiply the number and keep it at scienfitic notation the calculation should be:
Well, your ratio given is 18 to 4. so multiply both numbers (18 and 4) by some number and you will have an equivalent ratio. example: if you had 2 times as many people, then an equivalent ratio would be 18*2 to 4*2 = 36 to 8