* More than 40 proteins and glycoproteins involved in the complement system are synthesized by the liver, macrophages, epithelial cells, they are present in the blood in plasmatic form, membrane, some have an enzymatic activity, regulator or membrane receptorThese are elements of the humoral innate immune response, they fight infections, purify immune complexes and apoptotic bodies.
<span>There are indeed three ways to activate the complement:</span>
Classical pathway: Activated by Immunoglobulins in immune complexes, aggregated Immunoglobulins, DNA, CRP, apoptotic bodies .......it involves nine fractions, starting with C1, then C4, C2, C3, to form a classical C5 convertase, then, activation of C5, C6, C7, C8, C9.
Alternative pathway: activated by polysaccharides (bacterial endotoxin), vascular wall poor in sialic acid, aggregated IgE ...C3b like is the first component in the alternate channel cascade, it will create an amplification loop, and form an alternative C5 convertase.
Lecithin pathway: Activated by mannose, fucose (carbohydrate of microorganisms)The first component is the complex MBL / MASP1 / MASP2: "mannose-binding protein": works according to the same principle as the complex C1 of the classical way (MASP2 cleaves the C4 and the rest of the cascade is equivalent to that of the classical way).
the three ways have the same outcome: A C5 convertase (formed by one of the pathways) cleaves C5 into C5a and C5b: C5b is deposited far from other fractions on the antigenic surface. The fixation of C5b in the cell is followed by that of C6, C7, C8, and C9 (9 molecules of C9): formation of the membrane attack complex (MAC) ==> Death of the cell by osmotic shock
WORKING DISTANCE is space between the bottom of objective the lens and the surface of the slide.
The distance between front edge of the objective and the lens and the specimen surface ("with the surface of the cover glass in case of the cover glass objective lens") when the specimen is also focused.
The working distance (W.D.) which is determined by the linear measurement of the objective and front lens to the focal plane. In the general, the objective of the working distance decreases by the magnification and the numerical aperture of both increase. The working distance is the distance and from the front of the lens to be the focal plane
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The correct answer is d
Hope this helps :DD
Answer:
upside down
Explanation:
When images first appear into the eye, they are first flipped. They are flipped over when it is being processed by the brain.
Answer:
The answer D
Explanation:
The answer is in the question.
