Answer :Enhanceosome<span> Protein complex that binds enhancer elements and directs DNA bending into loops that bring the protein complex into contact with RNA polymerase and transcription factors bound at the core promoter or with protein complexes bound to proximal promoter elements.
</span>Answer: enhanceosome
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a large protein complex formed by the aggregation of multiple proteins, a few binding enhancer sequences and others binding other proteins.
They direct DNA bending into loops that bring the enhanceosome into contact with RNA polymerase and transcription factors bound at the core promoter or with protein complexes bound to proximal promoter elements.
The DNA loops can be small or large, in keeping with the observation that enhancers many be close to or quite distant from the genes they regulate.
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Mutations can lead to changes in the structure of an encoded protein or to a decrease or complete loss in its expression. Because a change in the DNA sequence affects all copies of the encoded protein, mutations can be particularly damaging to a cell or organism.
