Homeostasis can be defined as the state of maintenance of the constant internal conditions by the living organisms. The homeostasis is maintained by the body so that it may function properly. The homeostasis will be disturbed by the reduced intake of the food and water. Healthy intake of water and food is essential in maintaining the homeostasis of the body. The elevated or depressed blood pH along with extreme body temperatures will also disturb the homeostasis of the body making the person sick. Moreover, certain infectious organisms also alters the homeostasis of the body.
Hence, all the options are correct.
Answer:
Exosomes as Therapeutic Target
Given the fact that elevated exosome levels are often correlated with greater severity of different types of cancer, reducing circulating exosomes to normal levels is one of therapeutic strategies to increase treatment efficacy. There are different approaches to modulate exosome production: 1) Inhibition of exosome formation: inhibit crucial proteins involved in exosome formation pathway; 2) Inhibition of exosome release: inhibit important regulators of exosome release process, increased intracellular Ca2+, change cellular microenvironmental pH; 3) Inhibition of exosome uptake: add proteinase for surface proteins on exosomes may serve as receptors for uptake pathways. In addition to control exosomes production, removal of exosomes from the entire circulatory system might be a novel strategy for cancer treatment.
Exosomes could also be used as cancer immunotherapy becasue tumor-derived exosomes carry antigens that is a great source of specific stimulus for the immune response against tumors. Both tumor-derived and dendritic cell-derived exosomes have showed capability to stimulate tumor antigen-specific responses in experimental animal models and human clinical trials.
Exosomes as Targeted Drug Delivery Vehicles
Exosomes became one of the most common methods applied in drug delivery system because of several advantages they have. Firstly, exosomes normally have a small size 40-100 nm, which is more homogenous compared to other microvesicles. This will lead them to evade rapid clearance by the mononuclear phagocyte and enhances passage through fenestrations in the vessel wall. Secondly, due to their endogenous origin, they are less toxic for and better tolerated by the immune system. It facilitates them to avoid causing side effects that normally occur with synthetic nanoparticles. Additionally, the specific ligand or protein expressed on the exosome surface increases efficiency of cargo into the cytosol of the target cell, and therefore fewer off-target effects. Exosomes are generally found most useful as a drug delivery medium in cancer therapy, anti-inflammation and gene interference therapy such as transferring of miRNA.
There are different kinds of cargos encapsulated by exosomes, especially like siRNA or miRNA. The delivery of RNA is attracting because they are rapid degradation in cell circulation and have the limitation in passing through the membrane and in cellular uptake. Chemotherapeutics loaded into exosomes is also used for cancer therapy such as doxorubicin. In principle, there are four key components to achieve correct functionality and efficacy during exosomes drug delivery:1) Choosing the donor cell type to produce drug-carrying exosomes; 2) Using correspond methods to encapsulate the exosomes cargo; 3) Enhancing the specificity of cargo delivery by targeting peptides on the surface of the exosomes; 4) Administrating exosomes to target the area of disease.
Explanation:
https://www.creative-biostructure.com/exosome-applications-652.htm
Answer:
True
Explanation:
Organic catalyst that increase the rate of biochemical reactions in the cells of living organism s are called enzymes.The are proteins with active sites which are specific to a particular substrate, for enzyme-substrate complex and later enzyme product complex to formed.
They act by lowering the activation energy in the organic chemical reaction therefore increase the rate at which chemical reactions progress.
Hence when the reactions are too slow,activation energy are high,because enzymes are not available to catalyze the reaction fixing the active sites with the the substrates.
MRNA carries a transcript of the needed amino acids to tRNA and then to the rRNA ribosomal component.
The medicare part B involves coverage for immunization, Seasonal flu, seasonal H1N1 flu, pneumococcal vaccine and Hepatitis B.
<u>Explanation:</u>
Medicare is a popular insurance coverage for elderly Americans that operates in 4 different modules the part A covers for inpatient expenses , part B covers outpatient expenses, the part C covers alternate medications and the part D covers medicine purchase for part C. All the coverage consists only commercially available vaccines. So the above given vaccines covers in the section of part B of Medicare.
