* More than 40 proteins and glycoproteins involved in the complement system are synthesized by the liver, macrophages, epithelial cells, they are present in the blood in plasmatic form, membrane, some have an enzymatic activity, regulator or membrane receptorThese are elements of the humoral innate immune response, they fight infections, purify immune complexes and apoptotic bodies. <span>There are indeed three ways to activate the complement:</span> Classical pathway: Activated by Immunoglobulins in immune complexes, aggregated Immunoglobulins, DNA, CRP, apoptotic bodies .......it involves nine fractions, starting with C1, then C4, C2, C3, to form a classical C5 convertase, then, activation of C5, C6, C7, C8, C9.
Alternative pathway: activated by polysaccharides (bacterial endotoxin), vascular wall poor in sialic acid, aggregated IgE ...C3b like is the first component in the alternate channel cascade, it will create an amplification loop, and form an alternative C5 convertase.
Lecithin pathway: Activated by mannose, fucose (carbohydrate of microorganisms)The first component is the complex MBL / MASP1 / MASP2: "mannose-binding protein": works according to the same principle as the complex C1 of the classical way (MASP2 cleaves the C4 and the rest of the cascade is equivalent to that of the classical way).
the three ways have the same outcome: A C5 convertase (formed by one of the pathways) cleaves C5 into C5a and C5b: C5b is deposited far from other fractions on the antigenic surface. The fixation of C5b in the cell is followed by that of C6, C7, C8, and C9 (9 molecules of C9): formation of the membrane attack complex (MAC) ==> Death of the cell by osmotic shock
It takes 27 days, 7 hours, and 43 minutes for our Moon to complete one full orbit around Earth. This is called the sidereal month, and is measured by our Moon's position relative to distant “fixed” stars. However, it takes our Moon about 29.5 days to complete one cycle of phases (from new Moon to new Moon).
in-sequence amino acid - AAA, UGC, AUC, CAC, GCA, ACU
stop codon - UAA, UAG, UGA
Explanation:
From the amino acid chart, the start codon is represented by the codon AUG which also code for the amino acid methionine. There are three stop codons including UAA, UAG, and UGA. The stop codons signal the end of the translation process of the mRNA. Every other codon within the mRNA chain codes for different amino acids except methionine.
Hence, using the attached amino acid chart:
start codon - AUG
in-sequence amino acid - AAA, UGC, AUC, CAC, GCA, ACU