Translation proceeds in three phases: Initiation: The ribosome assembles around the target mRNA. The first tRNA is attached at the start codon. Elongation: The tRNA transfers an amino acid to the tRNA corresponding to the next codon.
This definition above refers to the geographic isolation.
It means exactly what it says in the definition - one species is left behind from the rest of the population, and it stays in that particular location, evolving and changing from the species and population it was once a part of.
No choice given but the development of nuclear weapons could be considered a negative consequence of the application of scientific knowledge for example when it was used on Hiroshima and Nagasaki killing and wounding 100's of 1000's of people.