The total amount of water in the planet
<span>An agent, such as radiation or a chemical substance, that causes genetic mutation.
So your answer is ....
B. an agent that causes mutation in DNA
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The evolution of organisms are based on the resources available in order for it to be capable of growth still. In the given choices above, the substance or chemical that changed over time is the supply of carbon dioxide which is an essential substance for photosynthesis. Thus, the answer the first choice.