At what age do children have the same pharmacokinetic response as an adult?

1 answer:

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Pharmacokinetics and pharmacodynamics are very different in children and adults. For the majority of drugs, in children as well as adults, a relationship exists between pharmacokinetics and pharmacodynamics. The pharmacokinetics of many drugs vary with age (Keams, 1998). For instance, because of the rapid changes in size, body composition, and organ function that occur during the first year of life, clinicians as well as pharmacokineticists and toxicologists are presented with challenges in prescribing safe and effective doses of therapeutic agents (Milsap and Jusko, 1994). Studies with adolescents reveal even more complexity in ding metabolism and differences in drug metabolism between the sexes.

Pharmacokinetics is very opposite in adults and children. A relationship exists between pharmacokinetics and pharmacodynamics, in most of the drugs. Pharmacokinetics varies in age because of the rapid changes in body, composition, and organ function that occur during the year of life. So they ensure to prescribe safe and effective doses. Studies reveals that adolescents reveal even more complexity during metabolism and differences in drug metabolism between the sexes.

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