The main molecule found in nucleus is called DNA(deoxyribonucleic acid). This molecule is made of subunits called nucleotides. A nucleotide is made of a nitrogenous base that can be adenine, thymine, guanine or cytosine; a five carbon sugar called deoxyribose and a phosphate group. This molecule controns protein synthesis. Proteins are crucial to the cell's function.
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Answer:
Bridgham et al. (2006) showed that the interaction between a steroid hormone (aldosterone-M) and its receptor (mineralocorticoid) evolved by Darwinian gradualism. In this work, the authors demonstrated a primitive affinity between the hormone and its receptor that was initially present in chemically similar but more ancient ligands. This result has implications in understanding the association between gene duplication and the evolution of hormone signaling pathways. For example, in invertebrates, this work reinforces the importance of gene duplication in the existing interaction between paralogous glucocorticoid receptors and their receptor mineralocorticoid genes that were derived from duplication (Thornton 2001).
The publications above cited are the following:
J.T. Bridgham, S.M. Carroll, and J.W. Thornton (2006). Evolution of hormone-receptor complexity by molecular exploitation. Science, 312(5770), 97-101.
JW Thornton. Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions, Proc Natl Acad Sci USA (PNAS), 2001, vol. 98 10 (pg. 5671-5676).
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By manipulating the substrates of the reaction, the enzyme can lower the necessary energy needed to make the reaction occur.
