Answer:
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Sulfa drugs, such as antibiotics that contain sulfonamides. Example: Some combination drugs such as Sulfamethoxazole-trimethoprim (Septra, Bactrim) and Erythromycin-sulfisoxazole contain sulfonamides. <span>
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This would directly affect the epidermis because blisters will develop within the surface of the skin. Having blisters on the epidermis will decrease the function of the skin to be an effective barrier to disease. This is because blisters are open wounds that are prone to infection. As infection passes through these openings, it will affect the dermis and the other layers of the skin. Bullae is actually an auto-immune skin disease.
Maybe because of global warming and the glacier water melting makING it bigger and deeper. (I hope this is the answer you are looking for)
