Answer:
PP ; Pp (note:- "P" purple, "p" pink)
Pp ; pp
Explanation:
75% purple offspring
25% pink offspring
I hope it helps.
Answer: option A - Constant in genotype and phenotype
Explanation:
Pan mixia is a situation in which an individual is just as likely to mate with another randomly chosen individual as any other in the population
In a situation as described in the question, sexual reproduction is limited to organisms of the same habitat, thus the genetic variation is reduced to the BAREST MINIMUM.
This results in Constancy in genotype and phenotype
Answer: Antigens
Explanation: The ABO system of blood grouping is based on the basis of the type of antigens that are present in the red blood cells. Erythrocytes is another name for the red blood cells. Antigens are molecules that are capable of eliciting immune response. There are two types of antigens: antigen A and B. Blood type A has only antigen A, blood type B has only antigen B, blood type AB has both antigen A and B while blood type O has no antigen (neither A nor B antigen).
Similarly, Rh trait is determined by the presence or absence of rhesus antigen in the erythrocytes. Rhesus antigen is an antigen first discovered in rhesus monkey. Rh+ indicates the presence of rhesus antigen in the red blood cells while Rh- indicates the absence of rhesus antigen in the red blood cells.
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Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
