Question

Which statement explains how a DNA mutation causes sickle-cell anemia?(1 point)

Answer 1

Answer:

DNA mutation causes a change in the amino acid sequence for hemoglobin, which causes a change in the shape

Explanation:

Sickle cell mutation is a mutation that affect the production of red blood cell that is needed for the transport of oxygen in the bloods stream.

sickle cell mutation is a result of change in the amino acid which are building blocks of the protein hemoglobin.

The protein is what gives red cells their color, it has two subunits. The alpha

and beta subunit. There is a change in the arrangements of amino acid sequence and that is the basis for the sickle cell shape, beta subunit has valine an amino acid at position 6 instead of the glutamic acid. This alteration results in sickle cell problems that occur in people.

Answer 2

Answer:

Explanation:

From the options:

The DNA mutation increases the number of amino acids in hemoglobin, which causes a change in the shape of red blood cells.

The DNA mutation causes a change in the amino acid sequence for hemoglobin, which causes a change in the shape of red blood cells.

The DNA mutation decreases the number of amino acids in hemoglobin, which causes a change in the shape of red blood cells.

O The DNA mutation prevents formation of hemoglobin, the absence of wirich causes a change in the shape of red blood cells.

The correct answer would be that "The DNA mutation causes a change in the amino acid sequence for hemoglobin, which causes a change in the shape of red blood cells. "

The sickle-cell anemia is caused by a change in the amino acid sequence of the hemoglobin - specifically, as a result of the substitution of the sixth amino acid, glutamic acid, by valine in the beta subunit of the proteins that make up the hemoglobin. A single base substitution causes glutamic acid to be changed to valine.

The normal hemoglobin is disc-shaped and is able to effectively carry oxygen in the blood, unlike the sickle-cell hemoglobin which has the sickle shape and is not able to effectively carry oxygen in the blood.