Low self esteem. This is lack of commitment or no goals.
Answer:
Opioids
Opioids are a class of drugs that include the illegal drug heroin, synthetic opioids such as fentanyl, and pain relievers available legally by prescription
By drinking a bad bottle of water
I believe the answer is D, because the other options are normal things that happen during stages of weight loss or puberty.
Hope this helps! :)