Answer:
Abstract
Background and purpose: The sodium channel is a primary target for treating central nervous system disorders such as epilepsy. In this study the anticonvulsant effect of BmK IT2, a sodium channel-specific neurotoxin, was evaluated in different animal models of epilepsy.
Experimental approach: Experiments were performed on freely moving rats made epileptic by administration of either pentylenetetrazole (PTZ) or pilocarpine. BmK IT2 (0.05–0.5 μg in 2 μl) was microinjected into the CA1 area and its effects on PTZ-induced widespread, seizure-like behaviour and cortex epileptiform EEG, as well as on pilocarpine-induced seizure-like behaviour and c-Fos expression were studied.
Key results: Intrahippocampal application of BmK IT2 dose-dependently inhibited PTZ-induced seizure-like behaviour, and reduced the numbers and duration of the high amplitude and frequency discharges (HAFDs) of the epileptiform EEG component induced by PTZ. Similarly, in the pilocarpine-induced status epilepticus (SE) model, BmK IT2 significantly prolonged the latency to onset of the SE, reduced the severity of SE and suppressed hippocampal c-Fos expression during SE.
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Emperors-became weaker regents(fujiwara)-became wealthy&powerful nobles-gained more land peasants-paid more taxes
I'm not sure I completely understand the question, but if it's what I'm thinking it would be false. Federal laws have the higher power.
Answer:
Attitude Object.
In psychology, an attitude object is a person, place, idea or almost anything else of what you make a judgment about. This can be positive or negative.
In this case, Jack's business proposal was his attitude object. He had been working hard to make the client accept it, and it was really important to him, at the point that when the client finally accepted, he loudly expressed his enthusiasm.
