José probably doesn't feel any pain because his body, during and after exercise released endorphins which are endogenous opioids. This endorphins promote a sense of satisfaction and pleasure, and make pain and discomfort feel irrelevant.
A. Osmosis is the answer for this question
The answer is A. When a potent drug is discovered, it has to undergo animal and human trials to test it ADMET (Absorption, Distribution Metabolism, Excretion, and Toxicity) properties. Using tissue cultures to test drugs, such as cancer drugs, prevents the incidence of subjecting humans to the unknown adverse effects of the drugs before the drugs are determined to be safe for use.
Respiration is one of them
To do the top of stored energy.