Chemistry as a subject has a significant importance in our daily lives and the society in general. Everything on the earth is made of chemicals. ... It also describes various chemical elements preset in the environment, their reactions, and effects on the environment.
<span>Firstly, it is the only substance on Earth that is in liquid form at the temperatures commonly found on the Surface of our planet. Secondly, it is a superb solvent, meaning that other substances regularly and easily dissolve into it. This allows water to carry nutrients to cells, and carry waste away from them.</span>
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
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Answer: 1/4
Explanation:
Firstly, in order for both parents to be type A and have children with type o blood, their blood types must both be Ao. Since o is a recessive blood type, a punnett square shows there is a 25% chance any child of theirs will have type o blood. If neither parent is color blind and they have a son who is, it implies that the mother is a carrier of colorblindness and has the genotype XᴮXᵇ. If you do a punnett square of the not colorblind father (XᴮY) and the mother, it shows that a daughter would have a 0% chance of being colorblind. Therefore colorblindess is irrelevent, since there is no possibility of the daughter not having normal color vision. In conclusion, there's a 25% chance she will have type o blood and not be colorblind, since the other 75% chance would be having type A blood and not being colorblind.
Answer:
some important abiotic factors Space, water, and climate all help determine a species population.
Explanation: