Question

Which of the following statements about gluconeogenesis in animal cells is true?

Answer 1

Answer:

C. THE CONVERSION OF FRUCTOSE 1,6-BISPHOSPHATE to fructose- 6- phosphate is not catalyzed by phosphofructokinase -1, the enzyme involved in glycolysis.

Explanation:

This statement is true as the enzyme involved in this step is FRUCTOSE-1,6-BISPHOSPHATASE.

Gluconeogenesis is the coversion of non-carbohydrate molecules (lactic acid, amino acids, glycerol) through the pyruvic acid into glucose in the cells.

This process takes place mainly in the liver and occurs during periods of fasting, starvation, low carbohydrate diets.

The pathway of gluconeogenesis involves eleven steps of enzymatic catalyzed reactions.

In the conversion of fructose 1,6- bisphosphate to fructose-6-phosphate is catalyzed by fructose 1,6-bisphosphatase and not by phosphofructokinase -1 which is involved in glycolysis. This step is a rate-limiting step of the pathway.

The conversion of glucose-6-phospahte to glucose is not catalyzes by hexokinase but glucose -6- phosphatase.