Tretinoin is a naturally occurring metabolite of retinol in the retinoid class, including natural and synthetic analogues. It is the acid form of vitamin AIt acts on cell growth and differentiation. Its main use is the treatment against acne thanks to its keratolytic and anti-inflammatory properties. Tretinoin is also used in the treatment of acute myeloid leukaemia type 3 (AML 3).
SIDE EFFECTS:
Among the expected effects, side effects may occur. Signs of an allergic reaction include: hives, difficulty breathing, swelling of the face, lips, tongue or throat;
It should be known that tretinoin can make you more sensitive to the sun, so use sunscreen every day, and wear protective clothing outdoors.
Cholesterol and triglycerides should be done before and during treatment because this drug could increase their values
Some patient with leukaemia treated by tretinoin has suffered from The syndrome of retinoic acid which is characterized by fever, dyspnea, acute respiratory distress...
Explanation:
When there is DNA shape mutation, one of the main things that could happend in the change of shape of the proteins, this creates a different pattern to arrange the nucleotids in the nuclei of the cells
Absorbed into the blood by the mature enterocytes on the upper third of the intestinal villi
Answer: .OH, O2-, H2O2
Explanation:
Reactive oxygen species (ROS) are chemically reactive and unstable species containing oxygen. ROS are formed when oxygen is partially reduced, thus they are all radicals with very high reactivity, attacking membrane proteins such as ion channels etc
Examples include peroxides (H2O2), superoxide (O2-), hydroxyl radical (.OH)
