Answer: All statements are correct.
A. DNA technology is used to identify hereditary diseases - True
B. DNA technology is used to produce medicines and hormones - True
C. DNA technology is used to identify mutations - True
D. DNA technology is used to map human genes on chromosomes.
E. DNA technology is used to identify paternity - True
Explanation:
A. Hereditary diseases are passed from <u>parents to offsprings</u> via the <u>transmission of defective genes</u> to the next generation. In principle, these genetic errors are present in the <u>somatic cells</u> of the parent, which are <u>replicated</u> as it is during the DNA replication process. Therefore, the <u>offsprings carry the same genetic error</u> causing the same hereditary disease. With the help of (recombinant) DNA technology, which is a set of modern biotechnological tools, it has helped us identify those genes which are associated with that particular disease.
B. The (recombinant) DNA technology has helped us <u>isolate specific genes</u> that produce specific enzymes/hormones. After isolating them, we can <u>incorporate these genes into the DNA of fast-growing model organisms</u> such as bacteria. These bacteria multiply and produce millions of copies of these enzymes through gene expression (<u>central dogma of life</u>) and thus in a relatively short time, we can achieve our product that can be used for treatments of disease in diseased organisms. An example is the enzyme <u>insulin</u>, which is produced in humans by the <u>INS gene</u>. When humans are not able to produce insulin due to diabetes, we can provide insulin externally. This insulin is previously cultured/produced in E. coli bacteria <em>in vitro</em> having that INS gene obtained from healthy human being.
C. Mutations are the <u>genetic errors</u> in the <u>DNA sequence</u> that occurs during DNA replication. With the help of DNA technology, we can determine the <u>sequence of a diseased organism</u> and then we can compare it with a healthy organism. This helps us find out where the mutation occurred.
D. With the help of (recombinant) DNA technology, we can easily identify the <u>position (locus) of each gene on the chromosome</u> as well as the <u>distance of two genes on a chromosome</u>. This technology has been extensively used in the Human Genome Project in the past 2 decades. As of today, the Human Genome Project has been accomplished with in-depth details of genetic elements in human DNA.
E. Since DNA is a hereditary material, we can easily identify our paternity through <u>DNA fingerprinting technologies</u> such as <u>whole genome sequencing</u> and <u>restriction fragment length polymorphism</u>. Nowadays, this technology is being used for commercial purposes where one can know easily his/her paternity at low cost and relatively short time.