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elixir [45]
3 years ago
10

How the process of natural selection canexplainhow evolution occurs?

Biology
1 answer:
harkovskaia [24]3 years ago
8 0
In natural selection, there are three main things you need to know. There must be a variance in the genepool of course, or else to selection or evolution will take place. There also must be a selective force and time. Now, lets say that there is a population of many colored moths. But lets say that the brown colored moth blends in with the environment. This means that predators (selective force in this case) will have a much harder time finding these brown moths instead of easily finding some of the other colored moths (variation). This means that the brown moths will survive at a much higher rate because the are harder to find, and over time, the gene pool will narrow down to just brown moths because the rest of the moths die out due to predators and competition. This also means that this moth species has evolved over time to just become the brown colored moths only. Hope you can understand this but feel free to ask for clarification.
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6 0
3 years ago
Based on the definitions of pharmacophore and privileged structure, outline essential structural features a 1,4-dihyrdopyridine
stiv31 [10]

Answer:

Explanation:

Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.

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1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.

1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.

A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,

antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .

Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.

2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.

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Inessa05 [86]

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Explanation:

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