Numerous antiepileptic medications, such phenytoin, have been designed to block voltage-gated sodium channels (VGSC) in neuronal membrane. In addition, multiple toxins and pharmacological modulators work by attaching to various biophysical states of the VGSC to cause their effects. Depending on how modulatory agents act, some VGSC states are stabilized or destabilized, altering the channel's biophysical properties. The first anticonvulsant to successfully treat epileptic disorders without causing undesirable side effects such as brain drowsiness was phenytoin.
Phenytoin has been indicated to block high-frequency neuronal activity potentials from the inner vestibule of the pore, as demonstrated by electrophysiological research and site-directed mutation.
Frequency and voltage both affect phenytoin binding.
There are theories that phenytoin interferes with the late sodium current that sustains depolarizations in epilepsy by blocking non-inactivated channels.
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Short fall of rain, less fertility of soil, seeds are not well gemernated
(forgot how to spell xD)
Hope this helps!
~ Kana ^^
the answer is thrombocytes
Answer:
A
Explanation:
Carbon dioxide is a gas at room temperature.
<span>The four main parts of a flower are: pistil, stamen, petals and sepals. The pistil is the female part of the flower, the stamen is the male part of the flower, the petals are the colourful parts of the flower while the sepals are the modified leaves which protect developing flower buds. The pistil is made up of the stigma, style and ovary while the stamen is made up of filament and anther.</span>
