Question

In the salvage of purines, hypoxanthine-guanine phosphoribosyl transferase (HGPRT) is responsible for which of the following processes:
a) guanine to guanosine monophosphate (GMP)b) inosine monophosphate to inosinec) adenine to adenosine monophosphate (AMP)d) hypoxanthine to xanthine

Answer 1

Answer:

a) guanine to guanosine monophosphate (GMP)

Explanation:

• Hypoxanthine-guanine phosphoribosyl transferase (HGPRT) is a transferase enzyme which is responsible for the conversion of guanine to guanosine monophosphate (GMP) and of hypoxanthine to inosine monophosphate.
• The primary function of HGPRT to salvage the purines from the DNA that has been degraded and thus reintroduce the purines into the purine synthetic pathway.