Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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Answer:
The speed at which the reactants change to products over a given time.
Explanation:
A chemical's <u>reaction rate</u><u> is the change in the concentration of a reactant or a product with time (in moles per second)</u>.
Remember that during a chemical reaction, reactants are converted to products. Or what is the same, products are formed at the expense of reactants. This can be represented:
reactants → products
Therefore,<u> the progress of a reaction can be followed measuring the decrease in concentration of the reactants or the increase in concentration of the products.</u>
According to the temperature and other parameters, the reaction rate can increase or decrease.
Despite their frequency in the intertidal zone, in tide pools, sea urchins can be found at many different depths and in any habitats. They can also be found in nearly any ocean temperature. Sea urchins inhabit the polar seas as well as the warm tropics.
Answer:
<u>Polygenic therapies are more likely to show </u><u>unintended effects</u><u> in other regions of the genome likely resulting in harmful diseases.</u>
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Explanation:
Gene therapy involves biotechnological techniques that add or remove gene sequences in the genome. These are typically used in eliminating harmful genes that cause genetic diseases or disorders and are generally thought to improve an individual's quality of life.
Polygenic traits are controlled by several genes. Similarly, polygenic diseases may be caused by variations in several gene sequences. These include hypertension, heart disease, and diabetes. Polygenic therapies are more likely to show unintended effects in other regions of the genome, leading to other deleterious disease-causing effects.
