Oral polio vaccine is highly effective and inexpensive (about US$0.10 per dose, or US$0.30 per child and its availability has bolstered efforts to eradicate polio. A study carried out in an isolated Eskimo village showed that antibodies produced from subclinical wild virus infection persisted for at least 40 years. Because the immune response to oral polio vaccine is very similar to natural polio infection, it is expected that oral polio vaccination provides similar lifelong immunity to the virus.
Contact immunity to polio can occur when attenuated poliovirus derived from the oral polio vaccine is excreted, and infects and indirectly vaccinates unvaccinated individuals.
Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA). Mitochondria are structures within cells that convert the energy from food into a form that cells can use.
