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cricket20 [7]
3 years ago
15

Why is gwas used for complex disease studies?

Biology
1 answer:
kramer3 years ago
4 0
A GWAS can be performed by actually genotyping as few as 300000 to 1million
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In Kerr and Wright's experiment with 96 fruit-fly populations, only 4 males and 4 females bred in each generation. After 16 gene
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2.Less than 73% of the populations would have only one allele present.

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The two alleles chosen do not affect the fitness of flies in the lab environment, so Kerr and Wright could be confident that if changes in the frequency of normal and forked phenotypes occurred, they would not be due to natural selection.

Using a larger breeding population would not be expected to alter the outcome of the experiment.

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In wild-type cells growing in nitrogen-rich medium, the size threshold to enter mitosis is high, and the G1/S size control is cryptic because cell division produces daughter cells with a size greater than the minimum required to initiate S phase. In these conditions, G2 is long and G1 is short. However, the cell size threshold to enter mitosis is greatly reduced when wild-type cells are shifted to medium with a poor nitrogen source, such as minimal medium with proline, isoleucine, or phenylalanine. In these conditions, wild-type cells initiate mitosis at a reduced cell size, generating two daughter cells that are smaller than the critical size threshold required to progress through G1/S

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