Yes, a mutation is a type of change because that's what a mutation is basically. For example when people are born with down syndrome that occurs because early in development when the chromosomes get copied over a mutation occurs causing them to have two copies of 21 chromosomes (some people even have three copies of 21 chromosomes.
This process is called meiosis. Mitosis produces two identical daugheter cells, each with 12 chrimosomes. Meiosis produces four daughter cells with 6 chromosomes.
